Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction

IMMUNOBIOLOGY Protein tyrosine phosphatase eC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling

Protein tyrosine phosphatase (PTP) e (PTPe) exists as 2 forms generated by alternative promoter usage. It has recently been reported that a cytosolic isoform of PTPe (PTPeC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)– and leukemia inhibitory factor–induced activation of Janus kinsases (JAKs), thereby suppressing STAT3 tyrosine phosphorylation and STAT3 signalin...

Protein tyrosine phosphatase epsilonC selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling.

Protein tyrosine phosphatase (PTP) epsilon (PTPepsilon) exists as 2 forms generated by alternative promoter usage. It has recently been reported that a cytosolic isoform of PTPepsilon (PTPepsilonC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)- and leukemia inhibitory factor-induced activation of Janus kinases (JAKs), thereby suppressing STAT3 tyrosine phosphoryla...

The Jak-STAT Signal Transduction Pathway in Melanoma

Identification of Drosophila genes modulating JAK/STAT signal transduction

Computer Modeling of JAK/STAT Signal Transduction Pathway

Cytokines regulate important cellular responses through signal transduction pathways. The computer modeling is a useful method to understand dynamic characteristics or regulatory mechanisms of signal transduction pathways. The ultrasensitivity of the mitogen-activated protein kinase cascade was shown by the simulation study [2]. Many cytokine receptors transduce signals by receptor bound JAK ki...